How Pharma Marketing Can Prove ROI—and Change Care

How Pharma Marketing Can Prove ROI—and Change Care

As scrutiny rises, pharmaceutical marketers are turning to data, AI and precision media to prove ROI—without losing sight of the physicians and patients they serve.

Pharmaceutical marketers are facing a higher bar than ever. Every dollar spent across digital and traditional media must now be justified—not only in reach, but in real-world impact. It is no longer enough to show that a campaign reached healthcare providers (HCPs). Marketers must demonstrate that it influenced how clinicians think, decide and ultimately care for patients.

A one-size-fits-all media strategy cannot meet that standard. The variability is too great—across patient needs, physicians’ educational gaps and their preferred ways of receiving information. To create meaningful impact, pharmaceutical marketers must move toward data-driven, AI-enabled strategies that align campaigns with how HCPs actually behave and where they choose to engage.

Done well, this approach allows marketers to build a nuanced, living picture of HCPs—and translate that insight into actionable media plans.

Adapting to a More Demanding Landscape

Few decisions are straightforward in today’s healthcare marketing environment.

Physicians want information that helps improve patient outcomes. Yet nearly 70 percent report feeling overwhelmed by the volume of data they are expected to process—a condition increasingly described as “data fatigue.” The result is burnout, but also risk: when relevant information is harder to identify, patient safety can suffer.

At the same time, marketing budgets remain largely flat. Established media channels are crowded. Costs are rising in staples like linear television, while expanding data privacy regulations are forcing brands to rethink how—and where—they invest.

Breaking through requires change.

HCPs increasingly expect the kind of personalized, intuitive experiences they encounter as consumers. That means moving beyond proxy signals and outdated assumptions, and instead listening directly to signals generated by physicians themselves. Timely, first-party engagement data enables more relevant outreach—and respect for clinicians’ limited time.

It also requires openness to less traditional channels. Gaming, audio and podcasts remain underused in pharmaceutical marketing, yet offer meaningful opportunities to reach HCPs in environments where attention is less fragmented.

Recent IQVIA Digital work illustrates the potential. In a large-scale HCP audio campaign, deterministic, physician-level engagement was measured across both streaming audio and podcasts—previously considered difficult, if not impossible. The campaign reached more than 6,000 unique HCPs and provided clear insight into how content consumption influenced downstream engagement.

Just as important, marketers must optimize faster. Exposure and engagement data now allow campaigns to be refined weekly—or even in real time—rather than waiting for quarterly reviews. On programmatic channels, speed is no longer a luxury; it is a requirement.

How to Get There

Executing more targeted campaigns across a broader mix of channels—and adjusting them continuously—requires focus in three critical areas.

Data and AI.

Data has long powered pharmaceutical marketing. AI expands that power, surfacing deeper insights and enabling faster, more informed decisions. But the most effective campaigns are not built by algorithms alone. They depend on what might be called co-intelligence: AI paired with human clinical expertise, creativity and empathy.

This makes connected, high-quality data essential. Without strong identity resolution and contextual accuracy, AI simply accelerates error. With them, marketers reduce the risk of hallucinations and gain the ability to understand HCPs at a more granular level—moving steadily from probabilistic toward deterministic identity resolution.

Predictive analytics can further align media spend with actual physician behavior, but only if marketers shift away from lagging indicators like claims data, which often arrive weeks late. Faster signals—such as lab data, combined with daily online behaviors like search, content engagement and intent modeling—offer a near real-time view of HCP interest. This allows investments to follow relevance, not habit.

Media measurement.

Impact does not require ubiquity. It requires precision.

Omnichannel strategies must operate as continuous feedback loops, using audience quality, reach and cost per target reached to guide optimization throughout a campaign’s life cycle.

Reach matters—but only when aligned with purpose. In rare disease launches, for example, broad linear television campaigns may generate awareness but little value. Precision targeting—through hyper-segmented channels or influential digital opinion leaders—often reaches fewer people, but delivers far stronger returns.

Cross-functional cohesion.

Agility fails without alignment. Commercial operations, brand marketing, analytics and technology teams must work toward shared KPIs, guided by a unified data and AI strategy.

AI should not be viewed simply as a cost-saving tool. For marketers, its real value lies in refinement—enabling faster action and more personalized engagement. Cross-functional alignment also helps organizations navigate a tightening regulatory environment, ensuring consistent guardrails around data use, especially when campaigns intersect with patient-linked or “halo” audiences.

Marketing That Moves

Pharmaceutical marketing that truly makes an impact is not about spending more. It is about spending smarter.

When data and AI are used with purpose, teams are aligned, and campaigns are continuously optimized, marketers can deliver communications that resonate with HCPs—and the measurable ROI leaders demand.

Because the smartest media does not shout.

It listens, learns and shows up—precisely when it matters most.